{"id":44121,"date":"2026-10-07T10:26:30","date_gmt":"2026-10-07T10:26:30","guid":{"rendered":"https:\/\/vut.ac.za\/?p=44121"},"modified":"2026-10-08T08:36:38","modified_gmt":"2026-10-08T08:36:38","slug":"vut-phd-study-investigates-african-medicinal-plants-for-uterine-fibroid-treatment","status":"publish","type":"post","link":"https:\/\/vut.ac.za\/nso\/vut-phd-study-investigates-african-medicinal-plants-for-uterine-fibroid-treatment\/","title":{"rendered":"Thuto ya VUT PhD e nyaki\u0161i\u0161a dimela t\u0161a kalafo t\u0161a Afrika bakeng sa kalafo ya fibroid ya popelo"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u201cMoithuti wa PhD wa VUT Gcobisa Manzane o t\u0161weledit\u0161e dinyaki\u0161i\u0161o t\u0161e di holofet\u0161ago t\u0161eo di bont\u0161hago ka fao dibjalo t\u0161a kalafo t\u0161e di kgethilwego t\u0161a Afrika di ka thu\u0161ago go rarolla ditshepedi\u0161o t\u0161a thutaphedi t\u0161eo di amanago le di-fibroid t\u0161a popelo.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>06 Diphalane 2026 | Pale ka:<\/strong> <strong>Sadiki Siphiwe<\/strong> <strong>| Seswant\u0161ho: Sifiso Nomzaza<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metsotso e 4 nako ya go bala.<\/p>\n\n\n\n<figure style=\"width: 100%; margin: 0 0 24px; padding: 0; background: #000;\">\n    <img decoding=\"async\" src=\"https:\/\/vut.ac.za\/wp-content\/uploads\/2026\/10\/FACS-VIVA-PRESENTATION-3.webp\" style=\"width: 100%; height: auto; display: block;\">\n    <figcaption style=\"width: 100%; margin: 0; padding: 8px 10px; text-align: left; color: #fff; font-size: 13px; font-weight: normal; background: #000; box-sizing: border-box;\">\n  Mohumagadi Gcobisa Valencia Manzane o t\u0161welet\u0161a dikhwet\u0161o go t\u0161wa nyaki\u0161i\u0161ong ya gagwe ya PhD yeo e hlahlobago bokgoni bja dibjalo t\u0161a kalafo t\u0161e di kgethilwego t\u0161a Afrika mabapi le difibroid t\u0161a popelo.\n    <\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Dinyaki\u0161i\u0161o t\u0161e di holofet\u0161ago t\u0161a moithuti wa PhD wa Yunibesithi ya Theknolot\u0161i ya Vaal (VUT) di hlahlobje dithoto t\u0161a thutaphedi t\u0161eo di ka bago gona t\u0161a dibjalo t\u0161a kalafo t\u0161a Afrika t\u0161e di kgethilwego mabapi le ditshepedi\u0161o t\u0161eo di amanago le di-fibroid t\u0161a popelo, e lego boemo bjo bo tlwaelegilego bjo bo amago basadi ba dimilione lefaseng ka bophara<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dikutollo di t\u0161weledit\u0161we ke Mohumagadi Gcobisa Valencia Manzane nakong ya se\u0161ene ya tlhagi\u0161o ya nyaki\u0161i\u0161o ya ka morago ga dithuto t\u0161a godimo yeo e bego e swerwe ka VUT\u2019s Auditorium 100 ka la 22 Lewedi 2026. Polelo ya gagwe ya go T\u0161wa ya PhD, yeo e nago le sehlogo se se rego \u201cAmeliorative Effect and Phytochemical Constituents of Selected African Medicinal Plants in Relation to Uterine Fibroid Pathophysiology\u201d, e hlahlobje ka fao dibjalo t\u0161a kalafo t\u0161a setlogo di ka kgonago go tsenya letsogo go dinyaki\u0161i\u0161o t\u0161a ka moso ka ga maphelo a basadi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Difibroid t\u0161a popelo ke dikgolo t\u0161eo e sego t\u0161a kankere t\u0161eo di t\u0161welelago ka gare goba go dikologa popelo gomme di ka hlola dika t\u0161a go swana le go t\u0161wa madi ka nako ye telele goba ye nt\u0161i ya go hlapa ga basadi, bohloko bja pelvic, le mathata a pelego. Gae\u0161ita le ge dikgetho t\u0161e di fapa-fapanego t\u0161a kalafo e tlwaelegilego di a hwet\u0161agala, t\u0161homi\u0161o ya t\u0161ona e ka tswalanywa le ditshenyagalelo t\u0161e dikgolo, ditla-morago t\u0161e mpe t\u0161eo di tswalanago le kalafo le phihlelelo e lekanyedit\u0161wego, kudu-kudu maemong ao a nago le methopo e nyenyane. Ditlhohlo t\u0161e, gotee le khuet\u0161o ye e t\u0161welago pele ya di- fibroid t\u0161a popelo boleng bja bophelo bja basadi ba bant\u0161i, di gatelela go nyakega ga nyaki\u0161i\u0161o ye e t\u0161welago pele ka ga mekgwa ye e \u0161irelet\u0161egilego, ye e fihlelelwago le ye e theilwego bohlatseng ya tlalelet\u0161o le ye mengwe.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Thuto ya Mohumagadi Manzane e be e lebelet\u0161e kudu dibjalo t\u0161e pedi t\u0161a kalafo t\u0161a Afrika, Gunnera perpensa le Albizia tanganyicensis. Mehuta ye mebedi ya dibjalo ka set\u0161o e kopant\u0161we ke ditsebi t\u0161a set\u0161o t\u0161a maphelo (THPs), t\u0161eo di begago gore kopanyo ya t\u0161ona e ka godi\u0161a go \u0161oma gabotse ga kalafo. Thutong ye, mehuta ye mebedi ya dibjalo e ile ya kopanywa (tekanyo ya 3:1) go loki\u0161et\u0161a bjalo ka sampole ya boraro, yeo e bit\u0161wago AGMix. Dinyaki\u0161i\u0161o di nyaki\u0161i\u0161it\u0161e dithoto t\u0161a thutaphedi t\u0161a tlhamo ye e kopant\u0161wego ge e bapet\u0161wa le ditoki\u0161et\u0161o t\u0161a dibjalo ka botee.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ge a hlalosa tlhohlelet\u0161o yeo e lego ka morago ga nyaki\u0161i\u0161o ye, Mohumagadi Manzane o lemogile gore gae\u0161ita le ge dibjalo t\u0161a kalafo e le kgale di diri\u0161wa mekgweng ya set\u0161o ya go fodi\u0161a, bohlatse bja thutamahlale bjo bo hlalosago mekgwa ya t\u0161ona ya go \u0161oma bo sa dut\u0161e bo lekanyedit\u0161we.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cO it\u0161e: \u201dGo na le bohlatse bjo bo lekanyedit\u0161wego bja thutamahlale bjo bo thekgago mekgwa ya bona ya go \u0161oma mabapi le pathophysiology ya fibroid ya popelo.\u201d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Thuto e be e nyaka go hlaola diprofaele t\u0161a dimela t\u0161a phytochemical, go sekaseka dithoto t\u0161a t\u0161ona t\u0161a antioxidant le anti-inflammatory, go sekaseka bokgoni bja t\u0161ona bja go fetola kgatelet\u0161ego ya oxidative; le go nyaki\u0161i\u0161a ditlamorago t\u0161a t\u0161ona go go kgona ga sele le dikarabelo t\u0161a disele t\u0161e di lebanego le pathophysiology ya fibroid ya popelo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ka maiteko a go kopanya tsebo ya set\u0161o le nyaki\u0161i\u0161o ya mahlale, dibjalo di ile t\u0161a hlaolwa ka thu\u0161o ya ditsebi t\u0161a maphelo t\u0161a set\u0161o pele di sekasekwa ka Setheong sa VUT sa Dikhemikhale le Theknolot\u0161i ya Diphedi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ge a t\u0161welet\u0161a dikhwet\u0161o t\u0161a gagwe, Mohumagadi Manzane o begile go ba gona ga metswako ye mmalwa ya bioactive, go akaret\u0161wa flavonoids, phenolic acids, triterpenoids, alkaloids le tannins. Metswako ye e kile ya tswalanywa le mediro ya antioxidant, anti-inflammatory le anti-fibrotic.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gare ga dikhwet\u0161o t\u0161e di lemogegago t\u0161a nyaki\u0161i\u0161o, Gunnera perpensa e bont\u0161hit\u0161e mo\u0161omo wo bohlokwa wa go lwant\u0161ha go ruruga, mola tlhamo ya AGMix e bont\u0161hit\u0161e mo\u0161omo wo o okedit\u0161wego go thibela t\u0161welet\u0161o ya mehuta ya oksit\u0161ene ye e arabelago ye e hlot\u0161wego ke LPS (ROS) ka dikaong t\u0161a laboratori. Ditekolong t\u0161e di theilwego godimo ga disele, ditsopolwa di bont\u0161hit\u0161e ditlamorago t\u0161a phapano go go kgona ga sele, ka AGMix e bont\u0161ha cytotoxicity ya fase go ya go disele t\u0161e di tlwaelegilego t\u0161e di lekilwego mola e t\u0161welet\u0161a ditlamorago t\u0161e kgolo go go kgonagala ga mothaladi wa disele t\u0161a kankere ya HeLa. Dikutollo t\u0161e di \u0161i\u0161inya kgonagalo ya mo\u0161omo wa go kgetha wa antiproliferative gomme di fa motheo wa nyaki\u0161i\u0161o ye nngwe ya dithoto t\u0161a thutaphedi t\u0161a tlhamo ye e kopant\u0161wego.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cGunnera perpensa, Albizia tanganyicensis, le AGMix di bont\u0161hit\u0161e dithoto t\u0161a phytochemical le t\u0161a thutaphedi t\u0161eo di lebanego le pathophysiology ya fibroid ya popelo,\u201d Mohumagadi Manzane o bolet\u0161e.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lega go le bjalo, o gatelet\u0161e gore dilo t\u0161eo di hwedit\u0161wego di emela bohlatse bja pele le gore go nyakega nyaki\u0161i\u0161o e oket\u0161egilego pele ga ge go ka lebelelwa dikgopelo le ge e le dife t\u0161a kalafo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dinyaki\u0161i\u0161o t\u0161a ka moso di tla akaret\u0161a dinyaki\u0161i\u0161o t\u0161a tlalelet\u0161o t\u0161a laboratori, dinyaki\u0161i\u0161o ka ga ditsela t\u0161a dihomoune, diteko t\u0161a ka gare ga mmele le, moo go lego maleba, diteko t\u0161a kliniki t\u0161e di hlamilwego gabotse go hloma polokego le go \u0161oma gabotse.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ge a nagani\u0161i\u0161a ka tlhagi\u0161o ye, Mohumagadi Mapula Mofokeng, moithuti wa Masters ka Lefapheng la Mahlale a Taolo, o bolet\u0161e gore se\u0161ene ye e laedit\u0161e ka fao dinyaki\u0161i\u0161o t\u0161a thuto di ka tsenyago letsogo ka gona go rarolla ditlhohlo t\u0161a nnete.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cSeo se ilego sa t\u0161welela go nna e bile go bona ka fao dinyaki\u0161i\u0161o t\u0161a ka morago ga dithuto t\u0161a godimo di ka rarollago ditlhohlo t\u0161a nnete t\u0161eo di amago dit\u0161haba mola gape di hlola dibaka t\u0161a tsebo ye mpsha le boitlhamelo,\u201d a realo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O okedit\u0161e ka gore diforamo t\u0161a tlhagi\u0161o ya nyaki\u0161i\u0161o di kgatha tema ye bohlokwa go hlabolla banyaki\u0161i\u0161i ba ka morago ga dithuto t\u0161a godimo ka go hlohlelet\u0161a kabo ya tsebo, go tsenela kudu le go ithuta go kopanya dithuto.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tlhagi\u0161o ya nyaki\u0161i\u0161o ya ka morago ga dithuto t\u0161a godimo e bopa karolo ya boikgafo bja VUT bja go t\u0161wet\u0161a pele bokgoni bja nyaki\u0161i\u0161o, boitlhamelo le khuet\u0161o ya set\u0161haba ka fase ga Leano la 2033+.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le ge e le gore go nyakega netefat\u0161o ye nngwe, dinyaki\u0161i\u0161o t\u0161a Mohumagadi Manzane di tsenya letsogo go sehlopha se se golago sa mo\u0161omo wa mahlale wo o nyaki\u0161i\u0161ago dibjalo t\u0161a kalafo t\u0161a Afrika le tema ya t\u0161ona yeo e ka bago gona go rarolla ditlhohlo t\u0161e di gatelet\u0161ago t\u0161a maphelo. E gatelela gape mohola wa go kopanya tsebo ya setlogo le mekgwa ya sebjalebjale ya mahlale go t\u0161welet\u0161a ditemogo t\u0161e mpsha t\u0161eo di ka holago set\u0161haba.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/eur01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fflic.kr%2Fs%2FaHBqjD6iMc&amp;data=05%7C02%7Cwebadmin%40vut.ac.za%7Cae8dcdb95fc447bfd9ec08df23b5f8f5%7C1bad55d667ff456480adf00bca599df9%7C0%7C0%7C639268936630598884%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=zC5FUoHrfG7ydic11z%2FYoEpuEsfIv9rQ07cpZn%2BZe%2BE%3D&amp;reserved=0\">Swara maitemogelo ka botlalo go Flickr <\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>&#8220;VUT PhD student Gcobisa Manzane presented promising research showing how selected African medicinal plants may help address biological processes associated [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":44231,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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