{"id":44121,"date":"2026-10-07T10:26:30","date_gmt":"2026-10-07T10:26:30","guid":{"rendered":"https:\/\/vut.ac.za\/?p=44121"},"modified":"2026-10-08T08:36:38","modified_gmt":"2026-10-08T08:36:38","slug":"vut-phd-study-investigates-african-medicinal-plants-for-uterine-fibroid-treatment","status":"publish","type":"post","link":"https:\/\/vut.ac.za\/st\/vut-phd-study-investigates-african-medicinal-plants-for-uterine-fibroid-treatment\/","title":{"rendered":"Phuputso ea PhD Univesithing ea VUT e hlahloba litlama tsa Afrika tsa meriana bakeng sa phekolo ea li-fibroid tsa popelo."},"content":{"rendered":"

\u201cMoithuti oa PhD oa VUT, Gcobisa Manzane, o hlahisitse lipatlisiso tse t\u0161episang tse bont\u0161ang kamoo litlama tse khethiloeng tsa Afrika tsa meriana li ka thusang ho sebetsana le mekhoa ea tlhaho e amanang le lifiibroide tsa popelo.\u201d<\/strong><\/p>\n\n\n\n

06 Mphalane 2026 | Pale ka:<\/strong> Sadiki Siphiwe<\/strong> Setshwantsho: Sifiso Nomzaza<\/strong><\/p>\n\n\n\n

Nako ea ho bala metsotso e 4.<\/p>\n\n\n\n

\n \n
\n Mofumahadi Gcobisa Valencia Manzane o hlahisa diphumano tsa dipatlisiso tsa hae tsa PhD tse hlahlobang bokgoni ba dimela tse kgethilweng tsa Afrika tsa kalafo mabapi le di-fibroid tsa popelo.\n <\/figcaption><\/figure>\n\n\n\n

Phuputso e t\u0161episang e entsoeng ke moithuti oa PhD Univesithing ea Theknoloji ea Vaal (VUT) e hlahlobile matla a tlhaho a ka bang teng a litlama tse khethiloeng tsa Afrika tse phekolang mabapi le lits'ebetso tse amanang le lifiibroide tsa popelo, e leng boemo bo tloaelehileng bo amang basali ba limilione lefat\u0161eng ka bophara.<\/p>\n\n\n\n

Diphuputso di ile tsa hlahiswa ke Mofumahadi Gcobisa Valencia Manzane nakong ya kopano ya hlahiso ya diphuputso tsa kamora dikirii e neng e tshwaretswe Holong ya 100 ya VUT ka la 22 Loetse 2026. Puo ea hae ea ho qeta PhD, e nang le sehlooho se reng "Phello e Ntlafatsang le Metsoako ea Khemikhale ea Limela tse Khethiloeng tsa Kalafo tsa Afrika mabapi le Ts'ebetso ea Mafu a Fibroid a Popelo", e ile ea hlahloba kamoo limela tsa lehae tsa kalafo li ka kenyang letsoho lipatlisisong tsa kamoso mabapi le bophelo bo botle ba basali.<\/p>\n\n\n\n

Lifibroide tsa popelo ke lihlahala tse sa kankelang tse holang ka popelong kapa haufi le eona, 'me li ka baka mat\u0161oao a kang ho ilela khoeli nako e telele kapa ka mali a mangata, bohloko ba noka, le mathata a ho tsoala. Leha mekhoa e fapaneng ea phekolo e tloaelehileng e le teng, t\u0161ebeliso ea eona e ka amana le lit\u0161enyehelo tse kholo, litla-morao tse mpe tse amanang le phekolo, le phihlello e fokolang, haholo-holo libakeng tse haelloang ke lisebelisoa. Liqholotso tsena, hammoho le t\u0161usumetso e tsoelang pele ea li-fibroid tsa popelo boleng ba bophelo ba basali ba bangata, li totobatsa tlhokahalo ea liphuputso tse tsoelang pele mabapi le mekhoa e meng e tlatsetsang e bolokehileng, e fumanehang habonolo, le e thehiloeng bopaking.<\/p>\n\n\n\n

Phuputso ea Mofumahali Manzane e ne e shebane le mefuta e 'meli ea limela tsa meriana tsa Afrika, e leng Gunnera perpensa le Albizia tanganyicensis. Mefuta ena e 'meli ea limela e tloaetse ho kopanngoa ke bahlokomeli ba bophelo ba setso (THPs), ba tlalehang hore motsoako oa tsona o ka matlafatsa katleho ea phekolo. Phuputsong ena, mefuta ena e 'meli ea limela e ile ea kopanngoa (ka tekanyo ea 3:1) ho etsa sampole ea boraro, e bitsoang AGMix. Phuputso e ile ea batlisisa lit\u0161obotsi tsa baeloang ka kopanelo ha e bapisoa le baeloang ka limela ka bonngoe.<\/p>\n\n\n\n

Ha a hlalosa sepheo sa phuputso ena, Mofumahadi Manzane o boletse hore leha dimela tsa meriana di se di sebedisitswe nako e telele mekgweng ya phekolo ya setso, bopaki ba saense bo hlalosang kamoo di sebetsang kateng bo ntse bo le fokolang.<\/p>\n\n\n\n

\u201c"Ho na le bopaki bo fokolang ba saense bo t\u0161ehetsang mekhoa ea tsona ea t\u0161ebetso mabapi le ts'ebetso e sa tloaelehang ea lithupa tsa popelo," a rialo.<\/p>\n\n\n\n

Phuputso e ne e ikemiselitse ho hlalosa boemo ba lik'hemik'hale tsa limela, ho lekola matla a tsona a ho loant\u0161a oksaehante le ho kokobetsa ho ruruha, ho hlahloba bokhoni ba tsona ba ho laola khatello ea oksaehante; le ho batlisisa litlamorao tsa tsona ho phelahalo ea lisele le likarabelo tsa lisele tse amanang le ts'ebetso ea lefu la li-fibroid tsa popelo.<\/p>\n\n\n\n

Ka boikitlaetso ba ho kopanya tsebo ea setso le lipatlisiso tsa saense, limela li ile tsa tsebahatsoa ka thuso ea litsebi tsa phekolo ea setso pele li hlahlojoa Setsing sa Khemistri le Biotechnology sa VUT.<\/p>\n\n\n\n

Ha a hlahisa liphuputso tsa hae, Mofumahali Manzane o tlalehile boteng ba metsoako e 'maloa e phelang, ho kenyeletsa li-flavonoid, li-phenolic acid, li-triterpenoid, li-alkaloid le li-tannin. Metsoako ena e se e ntse e amahanngoa le mesebetsi e thibelang oksaehaine, e kokobetsang ho ruruha le e thibelang ho hlahisa lesapo la ho hlohlona.<\/p>\n\n\n\n

Har'a liphuputso tsa bohlokoa tsa phuputso ena, Gunnera perpensa e bont\u0161itse t\u0161ebetso e kholo ea ho loant\u0161a ho ruruha, ha motsoako oa AGMix o bont\u0161itse t\u0161ebetso e ntlafalitsoeng ea ho thibela tlhahiso ea li-reactive oxygen species (ROS) tse bakoang ke LPS mefuteng ea laboratori. Litekong tse entsoeng ka lisele, metsoako e bont\u0161itse litlamorao tse fapaneng ho phelong ea lisele, moo AGMix e bont\u0161itseng chefo e tlase ho lisele tse tloaelehileng tse ileng tsa lekoa, ha e ntse e na le litlamorao tse matla ho phelong ea lisele tsa mofet\u0161e tsa HeLa. Liphuputso tsena li fana ka maikutlo a t\u0161ebetso e ka khethang ea ho thibela kholo ea lisele, 'me li fana ka motheo oa liphuputso tse tsoelang pele mabapi le lit\u0161obotsi tsa baeloji tsa motsoako o kopantsoeng.<\/p>\n\n\n\n

\u201c"Gunnera perpensa, Albizia tanganyicensis, le AGMix li bont\u0161itse lit\u0161obotsi tsa khemistri ea limela le tsa baeloji tse amanang le ts'ebetso ea mafu a lithibola tsa popelo," ho boletse Mofumahali Manzane.<\/p>\n\n\n\n

Leha ho le jwalo, o ile a toboketsa hore diphumano ke bopaki ba pele feela le hore ho hlokahala dipatlisiso tse eketsehileng pele tshebediso efe kapa efe ya kalafo e ka nahanelwa.<\/p>\n\n\n\n

Dipatlisiso tsa kamoso di tla kenyelletsa dithuto tse ding tsa laboratori, dipatlisiso ka mekgwa ya dihomoune, diteko tsa in vivo, mme, moo ho loketseng, diteko tsa bongaka tse ralilweng hantle ho tiisa polokeho le katleho.<\/p>\n\n\n\n

Ha a nahana ka nehelano, Mof. Mapula Mofokeng, moithuti oa Master's Lefapheng la Mahlale a Tsamaiso, o itse thupelo e bont\u0161itse kamoo lipatlisiso tsa thuto li ka kenyang letsoho ho rarolleng liqholotso tsa bophelo ba sebele.<\/p>\n\n\n\n

\u201c"Se ileng sa hlahella ho 'na e bile ho bona kamoo liphuputso tsa kamora mangolo a thuto a ka sebetsanang le liqholotso tsa sebele tse amang sechaba, ha ka nako e t\u0161oanang li theha menyetla ea tsebo e ncha le boqapi," a rialo.<\/p>\n\n\n\n

O boetse a re sethala sa lipuo tsa lipatlisiso se bapala karolo ea bohlokoa ho nts'etsapele bafuputsi ba li-postgraduate ka ho khothaletsa kabo ea tsebo, puisano e tebileng le thuto e kopanyang makala a fapaneng.<\/p>\n\n\n\n

Nehelano ea lipatlisiso tsa kamora dikirii e etsa karolo boitlamong ba VUT ba ho nt\u0161etsa pele bokhabane ba lipatlisiso, boqapi le t\u0161usumetso sechabeng tlas'a Leano la 2033+.<\/p>\n\n\n\n

Leha ho ntse ho hlokahala netefatso e eketsehileng, phuputso ea Mofumahali Manzane e tlatsetsa pokellong e ntseng e hola ea mosebetsi oa saense o fuputsang limela tsa meriana tsa Afrika le karolo eo li ka e bapalang ho sebetsana le mathata a tebileng a bophelo bo botle. E boetse e totobatsa bohlokoa ba ho kopanya tsebo ea setso le mekhoa ea saense ea sejoale-joale ho hlahisa temohisiso e ncha e ka tsoelang sechaba molemo.<\/p>\n\n\n\n

Bona boiphihlelo bo felletseng ho Flickr <\/a><\/p>","protected":false},"excerpt":{"rendered":"

“VUT PhD student Gcobisa Manzane presented promising research showing how selected African medicinal plants may help address biological processes associated […]<\/p>\n","protected":false},"author":4,"featured_media":44231,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[47,1],"tags":[],"class_list":["post-44121","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news-vaal-university-of-technology","category-uncategorized"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t